I previously used HyperX Cloud (60 ohm) and I was worried that DT250/80 might be a little much, but looks like I don't have to change anything at all to retain the volume. That was my concern, because UR242 is designed for 40 ohm in theory. With DT250, when I crank up everything to max, it's still a little too loud, so I guess that's fine (tested on Spotify/Youtube). They are comfy, but I'll see when I get to use them for a bit longer. They are also very light. And of course, big plus for replacable parts - headband, ear pads, cable. Cable is using a little screw, so it doesn't fall out. Small thing, but not an issue - coiled cable turns back into original position, so depending on your position, you might feel it pulling back a little, that's not a biggie though.
Sound wise - I don't really have good comparison, since those are my first headphones designed for proffessional use, but comparing to my previous ones they seem more natural, sound doesn't seem biased towards highs or lows. Listening to Spotify I started hearing their lossy quality, so I guess that's a good thing.