I use these strings to play low tuned metal with my ST-style guitar. They are most comfortable with a C# standard tuning, but can easily do C standard, Drop C and Drop B. They sound awesome! However, this set is in desperate need of a 22w 3rd string. Also, the sound starts getting dull after a month or so, but this is probably normal for non-coated strings.
All in all, it's a great set for a reasonable price and my personal daily driver for low tunings. Just make sure you replace the 22p string with a wound one!