I am a long term Jomox customer with an X-Base09, Airbase99 and now the Alpha Base mk2 so I feel qualified to make an informed judgement.
I won't explain the details of the architecture as it is well documented so will just keep this to my opinion.
I didn't buy the original Alpha Base as I hoped for a rack mount version so I could avoid the Jomox sequencer and use my Cirklon instead. I've been using Airbase99 with Cirklon for over 10 years so am embedded in that workflow.
When the mk2 was announced I decided I would try it and didn't expect to use the internal sequencer. That said, I gave it a go and am surprised to find it intuitive and enjoyable. So far I haven't connected my Cirklon but from looking at the midi spec, that will be an amazing combination.
Sound wise, Jomox always had special sauce but the increased flexibility of the Alpha Base sound engine is staggering. There are so many envelopes and filters, it's hard to know where to begin. This thing is ALL SWEET SPOT. Admittedly the Mbrane is still a challenge but I hear the possibilities. The FM synth is wonderful and the user manual explains it well.
If you are in the market for a product at this level, you really should give this a go. This and a looper would be enough for a live set.