I play bass, mostly in a metal context.
I use the Tyler for splitting the signal to a very compressed, clean bottom end (with an Empress Compressor) and a really distorted high end (with a DG Alpha-Omicron).
This is a ridiculously good combination in my ears. I used to use a Boss LS-2 for a similar kind of parallel mixing, but this was nowhere as good as the Tyler.
The pedal is build like a tank, there is no discernible noise and the sound quality and versatility is great. Though a bit intimidating at first, especially if you are not used to signal splitting, I found it pretty intuitive and didn't have a problem setting it up.
The only downside I can think of is its very large footprint, but this may not be an issue for everybody.