Search on youtube and internet something like "windows drivers problem MOTU". Sound popping, crackling, distorting on playback no matter of buffer size, settings, USB Windows settings in device manager (power options, disabling drivers and kepp ASIO only etc)...
Tried on multiple computers. And this is well known problem. Be aware if you planning to use it on Windows, MOTU drivers are junk.... And you can tell that it is computer or Windows problems - connected another USB to the same computer, same port, same settings - no any issues. No any issues whatever with integrated sound card. With MOTU it's like back to stone age...
Very disappointed, bought because of overhelmed positive reviews (assume most on Mac users). And even if some people do not have problems on their PC on Windows, it is not appropriated that device is working 50/50, like you are gambling...