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I got the Radial SB-6 to compare with the Palmer PLI-05 and Behringer HD400 for the purpose of removing extra noise from my pedalboard and amp setup. I am using a HX Effects in 4CM which is already notorious for adding some hiss but also ran into an issue of ground loop buzz in the FX loop of my amp (a modded Marshall). The Radial has the best features of all the three options but there was a very noticeable volume drop when routing the signal through the isolator. When used in the FX loop the volume clearly dropped about 6 dB and in front of the amplifier I seemed to lose a lot of gain and low end due to the level drop. So for me it was not working. The HD400 exhibits the same kind of volume drop so Palmer was the keeper here.